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Protein Data

See also: Sharing data on COVID-19 | Services for research on COVID-19

Available data on COVID-19

Reference resources

This section lists the main international reference resources for protein data. Among them are the ELIXIR Core Data Resources, a selection of European resources of fundamental importance to the life science community and the long-term preservation of biological data.

Resources at the European COVID-19 Data Portal

  • The European COVID-19 Data Portal is a resource developed at the European Bioinformatics Institute (EMBL-EBI) and proposes a collection of data like sequences, function and classification of SARS-CoV-2 and human proteins involved in the infection (the resource is based on UniProt data).

Resources developed in Italy

  • The Molecular INTeraction database (MINT) allows to annotate protein-protein interactions published in literature and manually curated by a team of experts. MINT is part of the ELIXIR Core Data Resources, developed at the Bioinformatics and Computational Biology Unit of the University of Rome Tor Vergata. MINT, together with other members of the IMEx consortium, recently annotated protein-protein interactions data between SARS-CoV2 and related strains of Coronaviridae and their host. Over 6900 molecular interactions from more than 220 scientific papers have been annotated and made publicly available.

  • The SIGnaling Network Open Resource database (SIGNOR 2.0) stores the signaling data published in literature in a structured format through binary causal relationships between biological entities, allowing their graphical representation as flows. The resource is developed and maintained at the Bioinformatics and Computational Biology Unit of the University of Rome Tor Vergata. The cellular pathways modulated during SARS-CoV2 infection are available at the COVID-19 Causal Networks page. SIGNOR 2.0 is part of the international project COVID-19 Disease Map.

  • MobiDB is a database for annotations on protein disorder and structural mobility/flexibility. The presence of disorder/flexibility in protein structures is known to facilitate interactions with partners such as enzymes and receptors, as well as to affect the protein function. The resource is developed at the BioComputing UP lab. of the University of Padua. A specific section has been developed for SARS-CoV-2 proteins such as Spike glycoprotein, predicted to be disordered at the C-terminal tail.

  • DisProt is a database of intrinsically disordered proteins where annotation is manually curated. The resource is developed at the BioComputing UP lab. of the University of Padua. A specific section is devoted to SARS-CoV-2 proteins.

Datasets produced by research groups in Italy

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Datasets

Papers & Preprints